The European Union's Scientific Steering Committee (SSC) produced a scientific opinion paper in 2002 on the use of non-human primates (NHP) in biomedical research. This paper made a series of statements about scientific research on NHP, and it has informed the EU's decision-making process on the matter. In our new report we address each of the statements made by the SSC. We discuss current scientific opinion on the issues raised, and the scientific basis for adopting non-animal alternatives in biomedical research.

Objective: To examine concordance between treatment effects in animal experiments and clinical trials. Conclusions: Discordance between animal and human studies may be due to bias or to the failure of animal models to mimic clinical disease adequately.

Clinical studies in human volunteers are an essential part of drug development. These studies are designed to account for possible differences between the effects of pharmaceutical products in preclinical studies and in humans. However, the tragic outcome of the recent Phase 1 clinical trial on TGN1412 casts considerable doubt over the relevance of this traditional drug development paradigm to the testing of therapeutic agents for human use. The role of alternatives to animal testing is considered, and a series of recommendations are made, which could ensure that clinical trials are well informed and based on the most relevant scientific information.

Assessment of the ethical and welfare implications of any laboratory animal use should encompass the entire life-history of the animals concerned, including their acquisition and transport. This is particularly important in the case of non-human primates, because the acquisition of some species involves capture from the wild, inadequate husbandry, and/or lengthy, multistaged travel from the country of origin to the laboratory where they are used. Thus, non-human primates endure considerable harms even before they reach the laboratory. Despite this, the information necessary to increase awareness of, and to assess, the potential harms of acquisition and transport is not readily available. This paper highlights the ethical and welfare concerns associated with these processes and makes recommendations intended to reduce their impact on welfare. The information presented is collated from a recent report that analyses the UK trade in non-human primates for research and testing, but many of the concerns and recommendations are applicable in an international forum. The need to minimise suffering is emphasised, as is the need for critical review of the necessity and justification for all non-human primate use, a reduction in the numbers used, and the development of alternatives to replace their use.

In this study, we dealt with 11 species of nonhuman primates across 10 zoos in India. We recorded behavior as instantaneous scans between 9 a.m. and 5 p.m. In the study, we segregated behaviors for analyses into abnormal, undesirable, active, and resting. The 4 types of abnormal behavior exhibited included floating limb, self-biting, self-clasping, and stereotypic pacing. In the study, we recorded 2 types of undesirable behavior: autoerotic stimulation and begging. Langurs and group-housed macaques did not exhibit undesirable behaviors. A male lion-tailed macaque and a male gibbon exhibited begging behavior. autoerotic stimulation and self-biting occurred rarely. Males exhibited higher levels of undesirable behavior than did females. Animals confiscated from touring zoos, circuses, and animal traders exhibited higher levels of abnormal behaviors than did animals reared in larger, recognized zoos. The stump-tailed macaque was the only species to exhibit floating limb, autoerotic stimulation, self-biting, and self-clasping. Our results show that rearing experience and group composition influence the proportions of abnormal behavior exhibited by nonhuman primates in captivity. The history of early social and environmental deprivation in these species of captive nonhuman primates probably is critical in the development of behavioral pathologies. Establishing this will require further research.